| Bioactivity | BRD4 Inhibitor-26 is a bromodomain protein 4 (BRD4) inhibitor/nitric oxide-donator. BRD4 Inhibitor-26 inhibits BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively. BRD4 Inhibitor-26 can be used for the research of ovarian cancer[1]. |
| Target | IC50: 0.82 μM (BRD4 (BD1)); 1.94 μM (BRD4 (BD2)); 1.38-8.47 μM (OC cells).Kd: 0.419 μM (BRD4 (BD1)); 0.686 μM (BRD4 (BD2)) |
| Invitro | BRD4 Inhibitor-26 (Compound 11a) 对BRD4 (BD1) 和 BRD4 (BD2) 具有抑制活性，IC50 值分别为 0.82 μM 和 1.94 μM[1]。BRD4 Inhibitor-26 对 BRD4 (BD1) 和 BRD4 (BD2) 具有抑制活性，Kd 值分别为 0.419 μM 和 0.686 μM[1]。BRD4 Inhibitor-26 对 OC 细胞具有抑制活性，IC50 值范围为 1.38-8.47 μM[1]。BRD4 Inhibitor-26 (0, 1.0 和 2.0 μM; 24 h) 显著降低 BRD4 和 c-Myc 的表达，并诱导细胞凋亡和自噬细胞死亡[1]。 Apoptosis Analysis[1] Cell Line: |
| In Vivo | BRD4 Inhibitor-26 (腹腔注射; 30 mg/kg) 在体内具有抗肿瘤活性并诱导细胞凋亡[1]。 Animal Model: |
| Name | BRD4 Inhibitor-26 |
| Formula | C29H27N5O6S |
| Molar Mass | 573.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yuehua Zhang, et al. Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator. Eur J Med Chem. 2023 Jan 15;246:114970. |