| Bioactivity | BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a Ki of 2 nM[1]. | ||||||||||||
| Target | RARα | ||||||||||||
| Invitro | BMS 753 results in low levels of RARβ transcripts in WT cells, RARγ-/-, but not activates in RARa-/- cells[1]. | ||||||||||||
| Name | BMS 753 | ||||||||||||
| CAS | 215307-86-1 | ||||||||||||
| Formula | C21H21NO4 | ||||||||||||
| Molar Mass | 351.40 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. M Géhin, et al. Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists. Chem Biol. 1999 Aug;6(8):519-29. [2]. R Taneja, et al. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RAR beta 2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12): 6 |