Apoptosis inducer 12_product_DataBase

Bioactivity	Apoptosis inducer 12 (Compound 3z) is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 12 can be used for the research of cancer[1].
Invitro	Apoptosis inducer 12 (Compound 3z; 72 h) 对 9 种人类肿瘤细胞 (白血病、非小细胞肺癌、结肠癌、中枢神经系统、黑色素瘤、卵巢癌、肾癌、前列腺癌和乳腺癌) 具有抗增殖活性，GI50 为 0.24-96.6 μM。白血病和前列腺细胞系对 Apoptosis inducer 12 的反应特别明显，GI50 值分别为 0.30-0.65 μM 和 0.43-0.84 μM [1]。Apoptosis inducer 12 (0.5-10 μM; 24 h) 阻断 A549、CCRF-CEM 和 VL51 细胞的中期细胞周期[1]。Apoptosis inducer 12 (0.5-5 μM; 48 h) 诱导 A549、CCRF-CEM 和 VL51 细胞凋亡[1]。 Cell Cycle Analysis[1] Cell Line:
Name	Apoptosis inducer 12
CAS	1971096-01-1
Formula	C27H29N3O5
Molar Mass	475.54
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Barreca M, et al. Identification of pyrrolo[3',4':3,4]cyclohepta[1,2-d][1,2]oxazoles as promising new candidates for the treatment of lymphomas. Eur J Med Chem. 2023 Jun 5;254:115372.

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