| Bioactivity | GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively). GW 583340 dihydrochloride reverses ABCG2- and ABCB1-mediated drug resistance. GW 583340 dihydrochloride has anti-cancer activity[1][2][3]. |
| Invitro | GW 583340 dihydrochloride (5 μM) 降低 Mitoxantrone 抑制 ABCG2-482-R2 和 ABCG2-482-T7 细胞系的 IC50 值[1]。GW 583340 dihydrochloride (2.5 和 7.5 μM，24 小时) 增加 SUM149 和 SUM190 细胞中 ROS 的积累，并诱导细胞凋亡[2]。GW 583340 dihydrochloride (0-10 μM) 减少 SCCF1 细胞和 CatMC 细胞中的集落形成[2]。 |
| Name | GW583340 dihydrochloride |
| CAS | 1173023-85-2 |
| Formula | C28H27Cl3FN5O3S2 |
| Molar Mass | 671.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sodani K, et al. GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance. Biochem Pharmacol. 2012 Jun 15;83(12):1613-22. [2]. Aird KM, et al. ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells. Breast Cancer Res Treat. 2012 Feb;132(1):109-19. [3]. Gray ME,et al. Dual targeting of EGFR and ERBB2 pathways produces a synergistic effect on cancer cell proliferation and migration in vitro. Vet Comp Oncol. 2017 Sep;15(3):890-909. |
GW583340 dihydrochloride
CAS: 1173023-85-2 F: C28H27Cl3FN5O3S2 W: 671.03
GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50: 0.01 and 0.014 μM respectively).
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