Antituberculosis agent-9_product_DataBase

Bioactivity	Antituberculosis agent-9 (Compound 5a) is an orally active antitubercular agent with an MIC of 0.5 μg/mL against H37Ra[1].
Invitro	Antituberculosis agent-9 (Compound 5a; 48 h) 显示出对 HepG2 细胞的细胞毒性，IC50 值为 3.1 μM[1]。Antituberculosis agent-9 (6 days) 对 MRSA、M. abscessus 和 M. smegmatis 有抑制作用，MIC 均为 4.0 μg/mL[1]。Antituberculosis agent-9 (6 days) 对临床分离的 M. tuberculosis 有抑制作用。对 H37Rv、K4、K12、K5、K16 的 MIC 值分别为 0.5、0.5、0.5、1.0 和 1.0 μg/mL[1]。
In Vivo	Antituberculosis agent-9 (Compound 5a; 300 mg/kg; oral; daily for 4 days) 对小鼠有中等抗结核作用[1]。 Animal Model:
Name	Antituberculosis agent-9
Formula	C25H29ClN4O
Molar Mass	436.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li C, et al. Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against Mycobacterium tuberculosis. J Med Chem. 2023 Feb 23;66(4):2699-2716.

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