| Bioactivity | Endochin is an antimalarial agent. Endochin inhibits T.gondii with an IC50 of 0.003 nM. Endochin is also active against experimental toxoplasmosis[1][2]. |
| Invitro | Endochin 抑制弓形虫细胞色素 bc1 复合物对细胞色素 c 的还原，IC50 为 8.2 nM[1]。Endochin 抑制 T. gondii 的 IC50 为 0.003 nM[1]。Endochin (Compound 1) 抑制 Plasmodium falciparum 分离出的多重耐药 W2 和 TM90-C2B 分离株，IC50 分别为 8.59 和 46.6 nM[2]。 |
| Name | Endochin |
| CAS | 354155-51-4 |
| Formula | C18H25NO2 |
| Molar Mass | 287.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Doggett JS, et al. Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15936-41. [2]. Cross RM, et al. Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity. J Med Chem. 2010 Oct 14;53(19):7076-94. |