| Bioactivity | Antibacterial agent 139 has antibacterial activity against Gram-positive bacteria. Antibacterial agent 139 has anti-MRSA, anti-VISA, and anti-LRSE activities. Antibacterial agent 139 depolarizes the bacterial cell membrane[1]. |
| Invitro | Antibacterial agent 139 (Compound 44) (18 h) 抑制形成生物膜的金黄色葡萄球菌和表皮葡萄球菌菌株的生长，MIC 值小于 12.5 μg/mL[1]。Antibacterial agent 139 (24 h) 显示出对肺和皮肤成纤维细胞系 (MCR-5 和 BJ) 的细胞毒性，IC50 分别为 12.5 和 >25 μg/mL[1].Antibacterial agent 139 (60 分钟) 在大鼠肝微粒体中代谢稳定，清除率较低 (8.94 μL/min/mg)[1]。Antibacterial agent 139 使细菌细胞膜去极化[1]. Cell Viability AssayAntibacterial agent 139 (Compound 44) (18 h) 抑制形成生物膜的金黄色葡萄球菌和表皮葡萄球菌菌株的生长，MIC 值小于 12.5 μg/mL[1]。 Cell Line: |
| Name | Antibacterial agent 139 |
| Formula | C28H29ClF3N3O2 |
| Molar Mass | 532.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Canale V, et al. Design and synthesis of novel arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines with antimicrobial activity against multidrug-resistant Gram-positive bacteria. Eur J Med Chem. 2023 May 5;251:115224. |
Antibacterial agent 139
CAS: F: C28H29ClF3N3O2 W: 532.00
Antibacterial agent 139 has antibacterial activity against Gram-positive bacteria. Antibacterial agent 139 has anti-MRSA
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