| Bioactivity | Anticancer agent 108 (Compound 3.10) is a potent P-gp inhibitor with significant antitumor activity and less toxicity to normal and pseudonormal cells. Anticancer agent 108 (Compound 3.10) had no acute toxic effect on С57BL/6 mice[1]. |
| Invitro | Anticancer agent 108（10 μM; 48 h）显著抑制癌细胞的增殖[1]。Anticancer agent 108（50, 100, 250, 500 nM; 72 h）抑制KB-3-1 cells的增殖[1]。Anticancer agent 108（0.5, 2.5, 5 μM; 3, 24 h）利用内质网（ER）应激诱导细胞凋亡[1]。Anticancer agent 108（5, 10 μM; 24 h）诱导MDA-MB-231细胞凋亡[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | Anticancer agent 108（单剂量，腹腔注射 20 mg/kg）不会引起动物体重下降、它们的快速死亡、白细胞减少症、红细胞减少症和小鼠血液中血红蛋白水平的降低。 Animal Model: |
| Name | Anticancer agent 108 |
| Formula | C18H9NO5S2 |
| Molar Mass | 383.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ivasechko I, et al. Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone). Eur J Med Chem. 2023 Apr 5;252:115304. |