Nrf2 activator-7_product_DataBase

Bioactivity	Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.
Invitro	Nrf2 activator-7 与 Keap1 的结合活性通过 fluorescence polarization （FP）测定的 IC50 值为 85 nM，通过 time-resolved fluorescence energy transfer （TR-FRET）测定的 IC50 值为 13.1 nM，并且 Ki 值为 4.9 nM[1]。Nrf2 activator-7（1、10、100 μM；24 h）增加 Nrf2 靶基因（GSTM3、HMOX1 和 NQO1）的转录[1]。 Real Time qPCR[1] Cell Line:
Name	Nrf2 activator-7
CAS	2456295-39-7
Formula	C35H32N2O11S2
Molar Mass	720.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Abed DA, et al. Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2023 Apr 5;252:115302.

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