| Bioactivity | Aβ-IN-6 reduces pro-inflammatory cytokine release from microglia cells. Aβ-IN-6 significantly induces Nrf2 nuclear translocation and hamperes Aβ oligomers formation. Aβ-IN-6 exerts a consistent neuroprotective effect by modulating the redox-sensitive signalling pathways in vivo oxidative stress model. Aβ-IN-6 is an orally active and has antiinflammatory, Antioxidant and Anti-oligomeric activity. Aβ-IN-6 has the potential for Alzheimer's disease (AD) research[1]. |
| Invitro | Aβ-IN-6 (化合物 4; 1-20 μM; 24 小时) 从 5 μM 的浓度开始显着降低小胶质细胞的活力[1]。 Aβ-IN-6 (1.25-40 μM; 24 小时) 在 SH-SY5Y 神经母细胞瘤细胞中浓度高于 2.5 μM 时有显着的细胞毒性[1]。 Aβ-IN-6 (2.5 μM; 3小时) 显着诱导 Nrf2 核转位[1]。 Aβ-IN-6 (2.5 μM) 显着抑制 LPS 诱导的两种细胞因子和 NLRP3 mRNA 水平的升高[1]。 Aβ-IN-6 (1, 2.5 μM; 预处理 1 小时然后用 LPS 刺激 24 小时) 显着降低 LPS 诱导的 TNF-α 和 IL-1β 的释放[1]。 Aβ-IN-6 (2.5 μM; 24 小时) 在叔丁基氢过氧化物 (t-BuOOH; 50 μM 30 分钟) 之前预处理，可以减少 ROS 形成，抑制率约为 18%[1]。 Cell Viability Assay[1] Cell Line: |
| In Vivo | Aβ-IN-6 (化合物 4; 10 μM; 添加到标准食物中) 有效地将神经退行性疾病 (D-spastin 功能丧失模型)下幼虫肌肉和大脑中增加的 ROS 水平恢复到在 Spastin 果蝇模型中观察到的对照水平[1]. Animal Model: |
| Name | Aβ-IN-6 |
| Formula | C28H31N3O4 |
| Molar Mass | 473.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ersilia De Lorenzi, et al. Targeting the multifaceted neurotoxicity of Alzheimer's disease by tailored functionalisation of the curcumin scaffold. Eur J Med Chem. 2023 Apr 5;252:115297. |