Antibacterial agent 141_product_DataBase

Bioactivity	Antibacterial agent 141 (Compound B14) has antibacterial activity against four plant pathogens Xoo, Xac, Psa and Cmm, with an EC50 value of 1.28 μM. Antibacterial agent 141 can inhibit the formation of cell membrane and change cell permeability.
Invitro	Antibacterial agent 141 显著诱导 Xoo 细菌的细胞膜破裂[1]。Antibacterial agent 141 在 Xoo 细菌中以浓度依赖性方式增加细菌膜通透性[1]。Antibacterial agent 141 破坏 Xoo 细菌的细胞膜表面[1]。Antibacterial agent 141 (3.2，6.4 μM) 显著降低 Xoo 细菌中 ACC、ACP 和 Fab 家族基因的表达[1]。Antibacterial agent 141随着浓度的增加显著抑制 Xoo 生物膜的形成[1]。Antibacterial agent 141 对 HepG2 和 HK-2 细胞毒性低[1]。Antibacterial agent 141 (0.64-5.12 μM；3-30 h) 显著抑制 Xoo 细菌的生长[1]。 Real Time qPCR Cell Line:
In Vivo	Antibacterial agent 141 (200 μg/mL；7 天；单剂量) 对白叶枯病的治疗和保护活性分别为 4.64% 和 43.33%[1]。
Name	Antibacterial agent 141
Formula	C23H27ClN2O3
Molar Mass	414.93
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu SS, et al. Novel spiro[chromanone-2,4'-piperidine]-4-one derivatives as potential inhibitors of fatty acid synthesis in pathogens: Design, synthesis, and biological evaluation. Eur J Med Chem. 2023 Mar 15;250:115215.

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