KRAS inhibitor-22_product_DataBase

CAS: 2042365-57-9 F: C23H21ClF4N2O5 W: 516.87

KRAS inhibitor-22 (compound FB9/6B9) is a potent inhibitor of K-Ras. KRAS inhibitor-22 targets to Kras 4B(G12D) and (G12

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	KRAS inhibitor-22 (compound FB9/6B9) is a potent inhibitor of K-Ras. KRAS inhibitor-22 targets to Kras 4B(G12D) and (G12C), which can be used for cancer research[1].
Invitro	KRAS inhibitor-22 (8 μM; 24 h) 在 25 ng/mL EGF 诱导的 MIAPaCa-2 细胞中降解 K-Ras(G12C)，在 L3.6pl 细胞中降解 K-Ras(G12D)[1]。 Western Blot Analysis[1] Cell Line:
Name	KRAS inhibitor-22
CAS	2042365-57-9
Formula	C23H21ClF4N2O5
Molar Mass	516.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. McCormick F, et al. Benzoylpiperidines and related compounds as K-Ras modulators and their preparation. World Intellectual Property Organization, WO2016179558 A1. 2016-11-10.

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