| Bioactivity | KHS101 is a small molecule that accelerates neuronal differentiation. KHS101 can distributes to the brain and resulted in a significant increase in neuronal differentiation[1]. |
| Invitro | KHS101 诱导贴壁培养大鼠 NPCs 神经元分化呈剂量依赖性 (EC50 ~ 1 μM)[1]。KHS101 (5 μM) 抑制 NPCs 星形胶质细胞形成[1]。KHS101 (5 μM; 24-72 h) 对 NPCs 细胞周期进程和增殖有负面影响[1]。KHS101 与 TACC3 蛋白特异性相互作用[1]。KHS101 (0-15 μM; 24 h) 调控转录因子 ARNT2 的核定位[1]。 RT-PCR[1] Cell Line: |
| In Vivo | KHS101 (6 mg/kg; s.c.; BID for 14 days) 在体内分布于大鼠脑内，显著促进神经元分化[1]。 Animal Model: |
| Name | KHS101 |
| CAS | 1262770-73-9 |
| Formula | C18H21N5S |
| Molar Mass | 339.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wurdak H, et al. A small molecule accelerates neuronal differentiation in the adult rat. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. |