| Bioactivity | Cathepsin L/S-IN-1 is a dual inhibitor of Cathepsin L and Cathepsin S with IC50s of 4.10 μM and 1.79 μM, respectively. Cathepsin L/S-IN-1 shows a significant antimetastatic and invasive effects on pancreatic cancer BxPC-3 and PANC-1 cells[1]. |
| Invitro | Cathepsin L/S-IN-1 (compound B1a) (0-25 μM; 48 h) shows noncytotoxic agaisnt pancreatic cancer BxPC-3 and PANC-1 cells[1].Cathepsin L/S-IN-1 (0-25 μM; 48 h) inhibits Cathepsin L and S activities without decreasing the mRNA level of them[1].Cathepsin L/S-IN-1 (0-25 μM; 48 h) inhibits the migration and invasion of pancreatic cancer BxPC-3 and PANC-1 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | Cathepsin L/S-IN-1 |
| Formula | C29H33BrN4O4S |
| Molar Mass | 613.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang H, et al. Design and synthesis of dual cathepsin L and S inhibitors and antimetastatic activity evaluation in pancreatic cancer cells. Bioorg Med Chem Lett. 2022 Nov 23;80:129087. |