Anti-inflammatory agent 47

CAS: 2925288-12-4 F: C25H18N2O3 W: 394.42

Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen

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Bioactivity	Flo8 is a potent anti-inflammatory and antioxidant compound. Flo8 inhibits the release of intracellular reactive oxygen species (ROS) and nitric oxide (NO) and suppresses neuronal apoptotic by inhibiting inflammatory and apoptotic signaling pathways. Flo8 can be used for Parkinson's Disease (PD) research[1].
Invitro	Compound Flo8 (5 μM, 10 μM, 18 小时) 对 BV2 细胞活力的抑制作用较小[1]。Compound Flo8 (5 μM, 18小时) 对 BV2 细胞中 ROS 的产生具有明显的抑制作用[1]。Compound Flo8 (5 μM, 10 μM, 18小时) 通过减少 BV2 细胞中炎症因子的表达，降低 SH-SY5Y 细胞的凋亡水平[1]。Compound Flo8 (5 μM, 10 μM, 18小时) 抑制 LPS 诱导的小胶质细胞 M1 极化，促进 M2 极化[1]。Compound Flo8 (5 μM, 10 μM, 18小时) 抑制 LPS 诱导的 BV2 细胞中 ERK，p38 和 JNK 磷酸化[1]。 Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Compound Flo8 (15/35 mg/kg，腹腔注射，每天/两周) 能缓解 MPTP 诱导 C57BL/6J 小鼠大脑中的神经炎症并抑制神经凋亡[1]。 Animal Model:
Name	Anti-inflammatory agent 47
CAS	2925288-12-4
Formula	C25H18N2O3
Molar Mass	394.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Shen ZB, et al. Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease. Eur J Med Chem. 2023 Jul 5;255:115417.

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