| Bioactivity | PRDX1-IN-1 is a selective inhibtor of PRDX1 with an IC50 value of 0.164 μM. PRDX1-IN-1 can be used in researches related to cancer.PRDX1-IN-1 promots intracellular ROS accumulation, and inhibits the proliferation, invasion and migration of cancer cells besides inducing apoptosis. PRDX1-IN-1 could be used in cancer research[1]. |
| Target | IC50:0.164μM(potent peroxiredoxin 1,PRDX1) |
| Invitro | PRDX1-IN-1 (compound 7e) 抑制人肺癌细胞 A549、肺癌细胞系（LTEP-a-2和H1975）、人乳腺癌细胞系（MDA-MB-231）、人肝癌细胞系（SK）的增殖活性 -Hep-1)，IC50 值分别为 1.92 μM，2.93 μM，1.99 μM，2.67 μM，2.42μM[1]。PRDX1-IN-1 (2 μM 或 4 μM, 24 h) 促进细胞内 ROS 积累，抑制癌细胞增殖、侵袭和迁移[1]。PRDX1-IN-1 (2 μM 或 4 μM, 24 h) 诱导 A549 细胞凋亡[1]。PRDX1-IN-1 (2 μM 或 4 μM, 6 h) 抑制 A549 细胞关键信号通路 (AKT 和 ERK) 并促进细胞凋亡相关蛋白 (cleaved caspase-3/8 和 cleaved PARP) 的表达[1]。 Proliferation assay[1] Cell Line: |
| In Vivo | PRDX1-IN-1 (0.5 或 1 mg/kg，i.p.，19 天，每天) 抑制小鼠肺癌模型中的肿瘤生长[1]。 Animal Model: |
| Name | PRDX1-IN-1 |
| Formula | C46H55N3O4 |
| Molar Mass | 713.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ying Bai, et al. Development of novel celastrol-ligustrazine hybrids as potent peroxiredoxin 1 inhibitors against lung cancer. Eur J Med Chem. 2023, 259, 115656. |