Anti-MRSA agent 7_product_DataBase

Bioactivity	Anti-MRSA agent 7 (Compound 12) is a potent antibacterial agent. Anti-MRSA agent 7 inhibits S. aureus DNA gyrase, E. coli DNA gyrase, S. aureus topo IV and E. coli topo IV with IC50s of 0.185, 0.365, 0.341 and 0.059 μM, respectively[1].
Invitro	Anti-MRSA agent 7 (Compound 12) 显示出剂量依赖性的杀菌效果，在处理后 8 小时内对游离态耐甲氧西林金黄色葡萄球菌（ATCC 43300）在 8 × MIC 浓度达到杀菌效果，之后会出现重新生长[1]。Antimicrobial activity of Anti-MRSA agent 7 (Compound 12) against a panel of Gram-positive and Gram-negative bacterial pathogens[1] Strain
In Vivo	Anti-MRSA agent 7 (Compound 12; 20 and 40 mg/kg; i.p.; QID for 1 day) 在 MRSA 中性粒细胞减少小鼠大腿感染模型中显示出较高的体内效果[1]。 Animal Model:
Name	Anti-MRSA agent 7
Formula	C22H20BrF2N3O4
Molar Mass	508.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kokot M, et al. Amide containing NBTI antibacterials with reduced hERG inhibition, retained antimicrobial activity against gram-positive bacteria and in vivo efficacy. Eur J Med Chem. 2023 Mar 15;250:115160.

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