| Bioactivity | AcrB-IN-1 (Compound H6) is a potent AcrB inhibitor. AcrB-IN-1 can be used for the reversal of bacterial multidrug resistance[1]. |
| Invitro | AcrB-IN-1 (Compound H6) 能在亚 MIC 浓度 (8-128 μg/mL) 下降低所测抗菌药物 (Erythromycin HY-B0220, Levofloxacin HY-B0330, Minocycline HY-17412A) 对大肠杆菌 BW25113 的 MIC 值[1]。AcrB-IN-1 (64 μg/mL) 不破坏细菌内膜[1]。AcrB-IN-1 在浓度为 50 μM 时完全消除尼罗河红 (已知的 AcrB 底物) 外排[1]。 |
| Name | AcrB-IN-1 |
| CAS | 2890177-82-7 |
| Formula | C32H39N3O4 |
| Molar Mass | 529.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148. |
AcrB-IN-1
CAS: 2890177-82-7 F: C32H39N3O4 W: 529.67
AcrB-IN-1 (Compound H6) is a potent AcrB inhibitor. AcrB-IN-1 can be used for the reversal of bacterial multidrug resist
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