| Bioactivity | Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer[1]. |
| Invitro | Albomycin 也与 FhuA 结合，与高铁色素竞争结合位点。FhuA 是埋在大肠杆菌外膜的 β 桶。或者，Albomycin 结合 FhuD，FhuD 是细胞膜 ABC 转运蛋白 FhuB/FhuC 的质周亚基[1]。Albomycin 对肺炎链球菌的生长有明显的抑制作用，最低抑制浓度为 4-62 nM[1]。 |
| Name | Albomycin |
| CAS | 1414-39-7 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Travin DY, et al. Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases. RSC Chem Biol. 2021 Feb 22;2(2):468-485. |