| Bioactivity | ALW-II-49-7 is a selective EphB2 kinase inhibitor with an EC50 value of 40 nM in cell[1]. | ||||||||||||
| Target | EphB2 | ||||||||||||
| Invitro | ALW-II-49-7 (化合物 9) 对一些激酶具有选择性，包括结合 b-raf, CSF1R，DDR1，DDR2，EphA2，EphA5，EphA8，EphB1，EphB2，EphB3，Frk，Kit，Lck，p38a，p38b，PDGFRa，PDGFRb 和 Raf1[1]。ALW-II-49-7 (0.01-10 μM; 1 h) 抑制 U87 胶质母细胞瘤细胞中 EphB2 激酶的活力，EphB2 的添加浓度为 2 μg/mL[1]。 | ||||||||||||
| Name | ALW-II-49-7 | ||||||||||||
| CAS | 1135219-23-6 | ||||||||||||
| Formula | C21H17F3N4O2 | ||||||||||||
| Molar Mass | 414.38 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Choi Y, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70. |