VU 0364739 hydrochloride_product_DataBase

Bioactivity	VU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research[1].
Invitro	VU 0364739 (1，5 和 10 μM；24，48，72 和 96 小时) 在无血清条件下时间和剂量依赖性地降低 MDA-MB-231 细胞活力[1]。VU 0364739 (1，10 和 100 μM；48 小时) 增加 Caspase 3 和 Caspase 7 活性。 Cell Proliferation Assay[1] Cell Line:
In Vivo	1.19Pharmacokinetic Properties of VU 0364739 in Rats[1].
Name	VU 0364739 hydrochloride
CAS	1244640-48-9
Formula	C26H28ClFN4O2
Molar Mass	482.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Lavieri RR, et al. Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J Med Chem. 2010 Sep 23;53(18):6706-19.

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