| Bioactivity | AHR antagonist 7 (compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of 1.4 nM[1]. |
| Invitro | In HepG2 cells, AHR antagonist 7 (CAY10464; 100 nM) inhibits CYP1A1 mRNA expression, and reverses the suppressive effect of Benzo[a]pyrene on apolipoprotein A-I (apo A-I) gene expression[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AHR antagonist 7 相关抗体: |
| CAS | 688348-37-0 |
| Formula | C15H12Cl2O |
| Molar Mass | 279.16 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Philippe de Medina, et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. J Med Chem. 2005 Jan 13;48(1):287-91. [2]. Emad Naem,et al. Inhibition of apolipoprotein A-I gene by the aryl hydrocarbon receptor: a potential mechanism for smoking-associated hypoalphalipoproteinemia. Life Sci. 2012 Jul 26;91(1-2):64-9. |
AHR antagonist 7
CAS: 688348-37-0 F: C15H12Cl2O W: 279.16
AHR antagonist 7 (compound 4j) is a selective and high-affinity aryl hydrocarbon receptor (AhR) antagonist with a Ki of
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