| Bioactivity | SR-3-65 (compound 6) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. SR-3-65 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway[1]. |
| Invitro | SR-3-65 (0.0001-100 µM, 48h) 抑制 AGS 细胞生长, IC50值为 24.75 μM[1]。SR-3-65(10 µM, 48-72 h) 在 AGS 和 MGC803 细胞中显示出抗迁移活性[1]。SR-3-65(10 µM, 48 h) 在 AGS 和 MGC803 细胞中上调 E-cadherin，下调 N-cadherin 和 vimentin 的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SR-3-65 相关抗体: Cell Viability Assay[1] Cell Line: |
| Formula | C16H9ClF3N3O2S |
| Molar Mass | 399.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hou C, et al. Subtle structural alteration in indisulam switches the molecular mechanisms for the inhibitory effect on the migration of gastric cancer cells. Biomed Pharmacother. 2024;172:116259. |