| Bioactivity | Anticancer agent 195 (Compound 10) is an inhibitor for ELF3-MED23 PPI with Ki of 0.68 μM. Anticancer agent 195 induces apoptosis and exhibits antitumor activity[1]. |
| Target | >Ki: 0.68 μM (ELF3-MED23 PPI) |
| Invitro | Anticancer agent 195 (10 μM) 阻断 ELF3-MED23 相互作用，抑制 HER2 启动子的活性以及 AKT 和 MAPK 磷酸化[1]。Anticancer agent 195 (10 μM) 在 NCI-N87 细胞中具有抗增殖和诱导凋亡的活性，可以对抗曲妥珠单抗的耐药性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anticancer agent 195 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | Anticancer agent 195 (4 mg/kg，静脉注射 25 天) 抑制无胸腺 NCI-N87 异种移植裸鼠体内的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C24H28O6 |
| Molar Mass | 412.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hwang SY, et al., Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as Novel Inhibitor for ELF3-MED23 Interaction, Cold Spring Harbor Laboratory, 2024 |