| Bioactivity | AChE/BChE/MAO-B-IN-4, an indan-1-one derivative, is a potent MAO-B inhibitor with an IC50 of 0.0393 μM for human MAO-B. AChE/BChE/MAO-B-IN-4 is a potent AChE and BChE enzyme inhibitor, with IC50s of 0.0458 μM and 0.075 μM for human AChE and BChE enzyme, respectively. AChE/BChE/MAO-B-IN-4 shows significant antioxidant activity and prevent β-amyloid plaque aggregation. AChE/BChE/MAO-B-IN-4 has the potential for Alzheimer's disease (AD) research[1]. |
| Invitro | AChE/BChE/MAO-B-IN-4 (compound D39) 对 NIH/3T3 成纤维细胞系的 IC50 值为 6.8118 μM[1]。 AChE/BChE/MAO-B-IN-4 (1 mM) 表现出对人 AChE 和 BChE 酶的强抑制特性，均产生 92% 的活性抑制[1]。 AChE/BChE/MAO-B-IN-4 对 β-淀粉样斑块聚集的 IC50 值为 0.1966 μM[1]。 |
| Name | AChE/BChE/MAO-B-IN-4 |
| Formula | C26H33N3O4 |
| Molar Mass | 451.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Begüm Nurpelin Sağlık, et al. Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents. ACS Omega. 2022 Dec 7;7(50):47378-47404. |