| Bioactivity | GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 µM. GABAA receptor agent 6 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1]. |
| Target | Ki: 0.56 µM (γ-GABAAR) |
| Invitro | GABAA receptor agent 6 (compound 2027) shows antagonist activity with IC50s of 6.68, 1.03, 0.36, 4.13, 4.96, 2.96, 0.29, 0.59 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1]. |
| Name | GABAA receptor agent 6 |
| CAS | 1808463-81-1 |
| Formula | C18H25N3O2 |
| Molar Mass | 315.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bavo F,et al. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. J Med Chem. 2021 Dec 23;64(24):17795-17812. |
GABAA receptor agent 6
CAS: 1808463-81-1 F: C18H25N3O2 W: 315.41
GABAA receptor agent 6 (compound 2027) is a potent γ-GABAAR antagonist with an Ki of 0.56 µM. GABAA receptor agent 6 s
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