| Bioactivity | AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC50 values of 0.809 µM, 2.248 µM and > 100 µM for hBChE, hAChE and hMAO-B, respectively. AChE/BChE-IN-6 penetrates the blood-brain barrier (BBB). AChE/BChE-IN-6 can be used for Alzheimer’s disease (AD) research[1]. |
| Invitro | AChE/BChE-IN-6 (compound 22) (1-100 µM; 48 hours) can cross the blood-brain barrier and has neuroprotective to human neuronal-like SH-SY5Y and liver HepG2 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | AChE/BChE-IN-6 |
| CAS | 2416910-94-4 |
| Formula | C23H30N2O2 |
| Molar Mass | 366.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Košak U, et, al. N-alkylpiperidine carbamates as potential anti-Alzheimer's agents. Eur J Med Chem. 2020 Jul 1;197:112282. |
AChE/BChE-IN-6
CAS: 2416910-94-4 F: C23H30N2O2 W: 366.50
AChE/BChE-IN-6 (compound 22) is a potent dual AChE/BChE inhibitor with IC50 values of 0.809 µM, 2.248 µM and > 100 µM
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