NPY5RA-972_product_DataBase

Bioactivity

NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1].

In Vivo

NPY5RA-972(p.o., 10.5 mg/kg) 在大鼠中的 Tmax 值为 1 小时，此时 Cmax 为 35 μM，半衰期为 6.4 小时，且即使在给药后 24 小时总血浆浓度仍大于3 μM/h[1]。NPY5RA-972 (p.o., 1-10 mg/kg) 抑制了由选择性 NPY Y5 受体激动剂引起的食物摄入，但对自由喂养的 Wistar 大鼠或膳食肥胖大鼠的摄食量或体重均无影响[1]。

Name

NPY5RA-972

CAS

439861-56-0

Formula

C21H25N3O2

Molar Mass

351.44

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Andrew V Turnbull, et al. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. 2002 Aug;51(8):2441-9.

PeptideDB

NPY5RA-972

CAS: 439861-56-0 F: C21H25N3O2 W: 351.44