| Bioactivity | (Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting both the c- and the ε-subunit. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[1][2]. |
| Name | (Rac)-Bedaquiline |
| CAS | 654655-80-8 |
| Formula | C32H31BrN2O2 |
| Molar Mass | 555.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Jun;55(6):483-487. [2]. Sarathy JP, et al. TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01540-19. |
(Rac)-Bedaquiline
CAS: 654655-80-8 F: C32H31BrN2O2 W: 555.50
(Rac)-Bedaquiline is the racemate of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacte
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