| Bioactivity | 17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90). 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway[1]. |
| CAS | 299173-64-1 |
| Formula | C28H42N2O7 |
| Molar Mass | 518.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhao S, et al., 17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells. J Bioenerg Biomembr. 2015 Oct;47(5):373-81. |
17-Demethoxy-reblastatin
CAS: 299173-64-1 F: C28H42N2O7 W: 518.64
17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90). 17-Demethoxy-reblastatin inhibits th
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