| Bioactivity | PNR-7-02 inhibits Pol η function with an IC50 value of near 8 μM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda (λ). PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring[1][2]. |
| CAS | 1633660-76-0 |
| Formula | C24H16ClN3O2S |
| Molar Mass | 445.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zafar M K, et al. Investigation of Structure‐Activity Relationships for Small‐Molecule Inhibitors of Human DNA Polymerase Eta[J]. The FASEB Journal, 2016, 30: 1052.3-1052.3. [2]. Ler AAL, et al. DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target. Front Oncol. 2022 Feb 7;11:822500. |
PNR-7-02
CAS: 1633660-76-0 F: C24H16ClN3O2S W: 445.92
PNR-7-02 inhibits Pol η functionwith an IC50 value of near 8 μM, which binds to the little finger domain. PNR-7-02 is
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.