(S)-Roscovitine_product_DataBase

Bioactivity	(S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke[1][2].
In Vivo	(S)-Roscovitine (25 mg/kg; i.p.; 15 min before and 1 hr after pMCAo) 在永久性大脑中动脉闭塞 (permanent middle cerebral artery occlusion) 成年小鼠模型中显示出神经保护功效[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	186692-45-5
Formula	C19H26N6O
Molar Mass	354.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Le Roy L, et al. Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. Cells. 2021 Jan 8;10(1):104. [2]. Menn B, et al. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 Aug 12;5(8):e12117.

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