| Bioactivity | NT-0249 free base is an orally active NLRP3 inhibitor. NT-0249 has anti-inflammatory activity[1]. |
| In Vivo | NT-0249 (100 mg/kg, 口服, 每天 3 次, 28 天) 可以减少小鼠预先建立的肥胖状态下的全身炎症和星形胶质细胞形成[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C22H29N5O4S |
| Molar Mass | 459.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Thornton P, et al. Reversal of High Fat Diet-Induced Obesity, Systemic Inflammation, and Astrogliosis by the NLRP3 Inflammasome Inhibitors NT-0249 and NT-0796. J Pharmacol Exp Ther. 2024;388(3):813-826. Published 2024 Feb 15. |