| Bioactivity | (S)-PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. (S)-PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research[1]. |
| Invitro | (S)-PM-43I (0.05-5 µM; 2 h) inhibits IL-4 stimulated phosphorylation of STAT6 in Beas-2B immortalized human airway cells[1]. Western Blot Analysis[1] Cell Line: |
| In Vivo | (S)-PM-43I (intranasal administration; 5 μg per mouse; every other day; 18 d) activity is restricted to the lung by intranasal administration[1]. Animal Model: |
| Name | (S)-PM-43I |
| CAS | 1637532-77-4 |
| Formula | C38H50F2N3O10P |
| Molar Mass | 777.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. John S. Mcmurray, et al. Stat6 inhibitors. WO2014182928A2. |
(S)-PM-43I
CAS: 1637532-77-4 F: C38H50F2N3O10P W: 777.79
(S)-PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. (S)-PM-43I can be used in allergic lu
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