| Bioactivity | (R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R,S,S)-VH032 synthesizes the tau-targeting small molecule PROTAC C004019 (HY-138669)[1]. | ||||||||||||
| Target | VHL | ||||||||||||
| Name | (R,S,S)-VH032 | ||||||||||||
| CAS | 2230826-33-0 | ||||||||||||
| Formula | C22H30N4O3S | ||||||||||||
| Molar Mass | 430.56 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11(11):5279-5295. |
(R,S,S)-VH032
CAS: 2230826-33-0 F: C22H30N4O3S W: 430.56
(R,S,S)-VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interactio
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