| Bioactivity | CDK2 degrader 2 is a PROTAC class CDK2 degrader. CBM binds to CDK2 protein and subsequently undergoes ubiquitination, thereby labeling CDK2 for degradation through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC50 value less than 100 nM and an average Dmax value greater than 75%. (Red: CBM; Blue: DIM; Black: linker) |
| CAS | 3030271-16-7 |
| Formula | C46H57ClN10O6S |
| Molar Mass | 913.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Collier, Philip, et al. CDK2 DEGRADERS AND USES THEREOF. US, US20240173419A1. 2024-05-30. |
CDK2 degrader 2
CAS: 3030271-16-7 F: C46H57ClN10O6S W: 913.53
CDK2 degrader 2 is a PROTAC class CDK2 degrader. CBM binds to CDK2 protein and subsequently undergoes ubiquitination, th
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