| Bioactivity | (3R,10R,14aS)-AZD4625 is the inactive isomer of AZD4625 (HY-146223), and can be used as an experimental control. AZD4625 (Compound 21) is a highly potent, selective, covalent and allosteric inhibitor of the mutant GTPase KRASG12C. AZD4625 has high oral bioavailability[1]. |
| Name | (3R,10R,14aS)-AZD4625 |
| Formula | C24H21ClF2N4O3 |
| Molar Mass | 486.90 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kettle JG, et al. Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRASG12C. J Med Chem. 2022 May 12;65(9):6940-6952. |
(3R,10R,14aS)-AZD4625
CAS: F: C24H21ClF2N4O3 W: 486.90
(3R,10R,14aS)-AZD4625 is the inactive isomer of AZD4625 (HY-146223), and can be used as an experimental control. AZD4625
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