| Bioactivity | Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell apoptosis, and inhibits tumor growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae)[1]. |
| Invitro | Lappaol F (72 h) 抑制 HeLa、MDA-MB-231、SW480 和 PC3 细胞的增殖，IC50 值分别为 41.5、26.0、45.3 和 42.9 μM，并诱导细胞凋亡[1]。Lappaol F (50 μM，12/24/36 h) 降低 HeLa、MDA-MB-231、SW480 和 PC3 细胞中 YAP 及其靶基因 (例如 BIRC5、GLI2、c-Myc、Bcl-2、Axin2 和 AREG) 的转录水平[1]。Lappaol F (0-50 μM，24-72 小时) 可降低 HeLa 细胞中的 YAP 蛋白水平、核定位和转录活性[1]。Lappaol F (50 μM，24-72 小时) 可诱导 HeLa、MDA-MB-231、MCF-7 细胞出现 G1 和 G2 细胞周期停滞[2]。 0 --> Lappaol F 相关抗体: Immunofluorescence[1] Cell Line: |
| In Vivo | Lappaol F (10 和 20 mg/kg/d，静脉注射，15 天) 抑制裸鼠体内人结肠癌 (SW480) 异种移植物的肿瘤生长[1]。 Animal Model: |
| Name | Lappaol F |
| CAS | 69394-17-8 |
| Formula | C40H42O12 |
| Molar Mass | 714.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li X, et al. Lappaol F, an anticancer agent, inhibits YAP via transcriptional and post-translational regulation. Pharm Biol. 2021 Dec;59(1):619-628. [2]. Sun Q, et al. Lappaol F, a novel anticancer agent isolated from plant arctium Lappa L. Mol Cancer Ther. 2014 Jan;13(1):49-59. |