| Bioactivity | (1R,3S)-Compound E is the inactive isomer of Compound E (HY-14176), and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively. |
| Name | (1R,3S)-Compound E |
| CAS | 504428-17-5 |
| Formula | C27H24F2N4O3 |
| Molar Mass | 490.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276(48):45394-402. [2]. Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100(12):1879-88. |
(1R,3S)-Compound E
CAS: 504428-17-5 F: C27H24F2N4O3 W: 490.50
(1R,3S)-Compound E is the inactive isomer of Compound E (HY-14176), and can be used as an experimental control. Compound
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