(R)-(-)-1,2-Propanediol is the (R)-enantiomer of 1,2-Propanediol, which is produced from E. coli expressing the NADH-linked glycerol dehydrogenase gene.

Physicochemical Properties

Molecular Formula	C3H8O2
Molecular Weight	76.09
Exact Mass	76.052
CAS #	4254-14-2
PubChem CID	259994
Appearance	Colorless to light yellow liquid
Density	1.0±0.1 g/cm3
Boiling Point	184.8±8.0 °C at 760 mmHg
Melting Point	-57ºC
Flash Point	107.2±0.0 °C
Vapour Pressure	0.2±0.8 mmHg at 25°C
Index of Refraction	1.430
LogP	-1.34
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Heavy Atom Count	5
Complexity	20.9
Defined Atom Stereocenter Count	1
SMILES	O([H])[C@]([H])(C([H])([H])[H])C([H])([H])O[H]
InChi Key	DNIAPMSPPWPWGF-GSVOUGTGSA-N
InChi Code	InChI=1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3/t3-/m1/s1
Chemical Name	(2R)-propane-1,2-diol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Microbial Metabolite
References	[1]. Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli. Appl Environ Microbiol. 1999 Mar;65(3):1180-5.
Additional Infomation	(R)-propane-1,2-diol is a propane-1,2-diol. It has a role as a human metabolite and an Escherichia coli metabolite. It is an enantiomer of a (S)-propane-1,2-diol. A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. (R)-Propane-1,2-diol is a metabolite found in or produced by Escherichia coli (strain K12, MG1655). R-1,2-Propanediol has been reported in Homo sapiens and Nicotiana tabacum with data available. See also: Propylene Glycol (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (1314.23 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (32.86 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (32.86 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (32.86 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	13.1423 mL	65.7117 mL	131.4233 mL
	5 mM	2.6285 mL	13.1423 mL	26.2847 mL
	10 mM	1.3142 mL	6.5712 mL	13.1423 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.