| Bioactivity | ω-Conotoxin CVIF is a selective Cav2.2 channel inhibitor with an IC50 of 34.3 nM in rat isolated DRG neurons. ω-Conotoxin CVIF block of Cav2.2 channels is weakly reversible[1]. |
| Target | IC50: 34.3 nM (Cav2.2 in rat isolated DRG neurons) |
| Name | ω-Conotoxin CVIF |
| Sequence | Cys-Lys-Gly-Lys-Gly-Ala-Ser-Cys-Arg-Arg-Thr-Ser-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Leu-Gly-Arg-Cys-NH2 (Disulfide bridge:Cys1-Cys16, Cys8-Cys20 and Cys15-Cys27) |
| Shortening | CKGKGASCRRTSYDCCTGSCRLGRC-NH2 (Disulfide bridge:Cys1-Cys16, Cys8-Cys20 and Cys15-Cys27) |
| Formula | C101H170N40O33S6 |
| Molar Mass | 2665.07 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Berecki G, et al. Effects of arginine 10 to lysine substitution on ω-conotoxin CVIE and CVIF block of Cav2.2 channels. Br J Pharmacol. 2014 Jul;171(13):3313-27. |
ω-Conotoxin CVIF
CAS: F: C101H170N40O33S6 W: 2665.07
ω-Conotoxin CVIF is a selective Cav2.2 channel inhibitor with an IC50 of 34.3 nM in rat isolated DRG neurons. ω-Conoto
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