| Bioactivity | γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system[1][2]. | ||||||||||||
| Invitro | γ-Aminobutyric acid (30 μM) depolarizes cortical progenitor cells (E16 cells), results an inward current in ventricular zone (VZ) cells, and induces DNA synthesis inhibition, with half-maximal response concentration of 5 μM[3].Cortical plate (cp) neurons expresses glutamic acid decarboxylase (GAD), γ-Aminobutyric acid (1-5 μM; 18 h) stimulates the motility and arrests the migration of cp cells, while the chemotropic signal is involved G-protein activation[4].γ-Aminobutyric acid activates GABA A receptors, causing cell cycle arrest in S phase and limiting growth[5]. Cell Migration Assay [4] Cell Line: | ||||||||||||
| Name | γ-Aminobutyric acid | ||||||||||||
| CAS | 56-12-2 | ||||||||||||
| Formula | C4H9NO2 | ||||||||||||
| Molar Mass | 103.12 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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γ-Aminobutyric acid
CAS: 56-12-2 F: C4H9NO2 W: 103.12
γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding
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