| Bioactivity | Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases[1][2][3]. |
| Invitro | Prostaglandin E1 (1 nM-10 μM; 48 h) concentration-dependently reduces HUVECs proliferation (up to 100% inhibition) in the presence of VEGF (20 ng/mL), with an IC50 of 400 nM[2].Prostaglandin E1 (0.01-10 μM; 6 h) inhibits VEGF-induced HUVECs migration in a concentration dependent manner, with an IC50 of 500 nM[2].Prostaglandin E1 (1-5 μM; 12-18 h) inhibits in vitro angiogenesis[2].Prostaglandin E1 (0.01-10 μM; 20 min) increases intracellular cAMP levels in HUVECs[2]. |
| Name | Prostaglandin E1 |
| CAS | 745-65-3 |
| Formula | C20H34O5 |
| Molar Mass | 354.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
Prostaglandin E1
CAS: 745-65-3 F: C20H34O5 W: 354.48
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for m
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