β-Casomorphin, bovine_product_DataBase

Bioactivity

β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1].

Target

IC50: 14 μM (Opioid receptor)

Invitro

β-Casomorphin, bovine (0.1 μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment[2].β-Casomorphin, bovine (0.1 μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels[2].β-Casomorphin, bovine do not modify the expression of rMuc1, rMuc4, and rMuc5AC[2].β-Casomorphin, bovine (0.1 μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human)[2].

In Vivo

β-Casomorphin, bovine (7.5×10−6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3].β-Casomorphin, bovine (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3].β-Casomorphin, bovine (7.5×10−6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3].β-Casomorphin, bovine (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3]. Animal Model:

Name

β-Casomorphin, bovine

CAS

72122-62-4

Sequence

Tyr-Pro-Phe-Pro-Gly-Pro-Ile

Shortening

YPFPGPI

Formula

C41H55N7O9

Molar Mass

789.92

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture and light, under nitrogen

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Reference

[1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. [3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.

PeptideDB

β-Casomorphin, bovine

CAS: 72122-62-4 F: C41H55N7O9 W: 789.92