| Bioactivity | αA-Conotoxin PIVA is a selective mouse musclenAChR inhibitor with IC50 for adult and fetal mouse musclenAChR sub> values are 2.3 nM and 22 nM respectively. αA-Conotoxin PIVA can be used in the study of neurological diseases. |
| Target | IC50: 2.3-22 nM (nAChR). |
| Name | αA-Conotoxin PIVA |
| CAS | 171439-59-1 |
| Sequence | Gly-Cys-Cys-Gly-Ser-Tyr-{Hyp}-Asn-Ala-Ala-Cys-His-{Hyp}-Cys-Ser-Cys-Lys-Asp-Arg-{Hyp}-Ser-Tyr-Cys-Gly-Gln-NH2 (Disulfide bridge:Cys2-Cys16, Cys3-Cys11, Cys14-Cys23) |
| Shortening | GCCGSY-{Hyp}-NAACH-{Hyp}-CSCKDR-{Hyp}-SYCGQ-NH2 (Disulfide bridge:Cys2-Cys16, Cys3-Cys11, Cys14-Cys23) |
| Formula | C103H150N34O37S6 |
| Molar Mass | 2648.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Teichert RW, et al. Definition and characterization of the short alphaA-conotoxins: a single residue determines dissociation kinetics from the fetal muscle nicotinic acetylcholine receptor. Biochemistry. 2006 Jan 31;45(4):1304-12. |
αA-Conotoxin PIVA
CAS: 171439-59-1 F: C103H150N34O37S6 W: 2648.89
αA-Conotoxin PIVA is a selective mouse musclenAChR inhibitor with IC50 for adult and fetal mouse musclenAChR sub> value
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