α2C adrenoceptor agonist 1_product_DataBase

Bioactivity	α2C adrenoceptor agonist 1 (Compound A) is an orally active, highly selective, and non-central nervous system penetrating agonist for the α2C-adrenoceptor, with EC50 and Ki values of 108 nM and 12 nM, respectively. α2C adrenoceptor agonist 1 can be used in the study of nasal congestion[1].
In Vivo	α2C adrenoceptor agonist 1 (Compound A) (5 mg/kg; p.o.; 单剂量) 在 Sprague-Dawley 大鼠中的脑渗透性较差，其平均 Cmax、Tmax 和曲线下面积值分别为 0.8 μM、0.7 h和2 μM•h[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	928115-79-1
Formula	C16H21N5O2
Molar Mass	315.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Corboz MR, et al. Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A). J Pharmacol Exp Ther. 2011;337(1):256-266.

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