| Bioactivity | UK4b is a highly selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. UK4b possesses anti-inflammatory and analgesic effects. UK4b can block the growth of abdominal aortic aneurysms in mice[1]. |
| In Vivo | UK4b (10-20 mg/kg; s.c.;一天两次连续 22 天) 能阻断 ApoE−/−血管紧张素 (Ang) II (1000 ng/kg/min; 输注,连续 28 天) 诱导的腹主动脉瘤 (AAA) 小鼠模型中腹主动脉瘤 (AAA) 的进一步生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 2171000-87-4 |
| Formula | C21H25ClN2O4 |
| Molar Mass | 404.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Weaver L M, et al. A highly selective mPGES-1 inhibitor to block abdominal aortic aneurysm progression in the angiotensin mouse model[J]. Scientific Reports, 2024, 14(1): 6959. |