| Bioactivity | α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-AR agonist 1 exhibits a hypnotic effect, with ED50 of 0.138 mg/kg in the loss of righting reflex (LORR) experiment. α2A-AR agonist 1 exhibits metabolic stability in mouse liver microsomes[1]. |
| CAS | 2971825-58-6 |
| Formula | C12H11BrN2O |
| Molar Mass | 279.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lv X, et al., Designing Chromane Derivatives as α2A-Adrenoceptor Selective Agonists via Conformation Constraint. J Med Chem. 2024 Jun 18. |
α2A-AR agonist 1
CAS: 2971825-58-6 F: C12H11BrN2O W: 279.13
α2A-AR agonist 1 (Compound B9) is a selective agonist for α2-adrenergic receptor (α2A-AR) with EC50 of 0.23 nM. α2A-
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