| Bioactivity | Bcl-2-IN-20 (Compound 81) is an inhibitor for Bcl-2 with IC50 10 μM), A549 (IC50=6.1 μM), HepG2 (IC50>10 μM), MCF-7 (IC50=8.9 μM), HCT116 (IC50>10 μM) and HEK-293 (IC50=14.1 μM). Bcl-2-IN-20 promotes the ROS production, induces apoptosis and DNA damage[1]. |
| Formula | C22H14BrNO6S |
| Molar Mass | 500.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Galla MS, et al., Development of chromone-thiazolidine-2,4-dione Knoevenagel conjugates as apoptosis inducing agents. Bioorg Med Chem Lett. 2024 Sep 1;109:129853. |