| Bioactivity | α-Isopropylmalate (α-IPM) is the leucine biosynthetic precursor in Yeast[1]. |
| Invitro | α-Isopropylmalate (500 μM) increases LEU3 protein (Leu3p)-dependent transcription[1].α-Isopropylmalate (10 mM, 48 h) increases reporter gene expression in preadipocytes (30A5)[2]. |
| Name | α-Isopropylmalate |
| CAS | 3237-44-3 |
| Formula | C7H12O5 |
| Molar Mass | 176.17 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Sze JY, et al. In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Science. 1992 Nov 13;258(5085):1143-5. [2]. Guo H, et al. Regulation of transcription in mammalian cells by yeast Leu3p and externally supplied inducer. FEBS Lett. 1996 Jul 22;390(2):191-5. |